NCT07076914

Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy

Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy: A Randomized Clinical Trial

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 58 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A randomized controlled trial to assess the impact of prophylactic proton pump inhibitor use to improve esophagitis in lung cancer patients undergoing radiation. Patients will be randomized into a standard of care arm or the prophylactic proton pump (daily) arm.

Conditions

• Primary Lung Cancer
• Non Small Cell Lung Cancer
• Small Cell Lung Cancer

Interventions

Type	Name	Description
DRUG	Experimental (Health Canada Approved Proton Pump Inhibitors)	The intervention uses a proton pump inhibitor as a preventative measure

Timeline

• Start date: 2025-10-02
• Primary completion: 2028-01-02
• Completion: 2032-10-02
• First posted: 2025-07-22
• Last updated: 2025-07-22

Locations

1 site across 1 country: Canada