Trials / Completed
CompletedNCT07076732
Beyond Platelet Indices, WBC-to-MPV Ratio in Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) Correlate With Short-Term Rather Than In-Hospital Outcomes
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 80 (actual)
- Sponsor
- Sohag University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to evaluate the role of platelet indices and the \[White blood cell (WBC) /mean platelet volume (MPV)\] ratio in correlation with angiographic profiles of patients diagnosed with myocardial infarction with non-obstructive coronary arteries (MINOCA) to assess their predictive value for short-term clinical outcomes.
Detailed description
Globally, ischemic heart disease remains a significant cause of death, and its prevalence constantly increases. Around 5-15% of acute myocardial infarction (AMI) patients show nonobstructive (\<50% stenosis) coronary arteries, named myocardial infarction with nonobstructive coronary arteries (MINOCA). There are two main phases of inflammation during myocardial infarction: the inflammatory phase and the proliferative phase. The white blood cell (WBC) count and its subtypes have been investigated as potential predictors of cardiovascular outcomes in patients with coronary artery disease (CAD), serving as inflammatory markers. The mean platelet volume (MPV) is determined in the progenitor cell, the bone marrow megakaryocyte. The platelet volume is found to be associated with cytokines (thrombopoietin, interleukin-6, and interleukin-3) that regulate megakaryocyte ploidy and platelet number and result in the production of larger platelets.
Conditions
- Platelet Indices
- White Blood Cell
- Mean Platelet Volume
- Myocardial Infarction
- Obstructive Coronary Arteries
- Short-Term Outcomes
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Coronary Angiography | Coronary angiograms will be acquired digitally for quantification. |
| OTHER | SYNTAX Score | Upon retrieval of a version from http://www.syntaxscore.com, the anatomical SYNTAX score will be implemented to numerically evaluate the intricacy of coronary lesions. |
Timeline
- Start date
- 2025-01-01
- Primary completion
- 2025-07-10
- Completion
- 2025-07-10
- First posted
- 2025-07-22
- Last updated
- 2026-03-13
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT07076732. Inclusion in this directory is not an endorsement.