NCT07076108

Oral Vitamin C Administration on Erythropoietin Dosing Requirement in End-Stage Renal Disease Patients on Regular Hemodialysis

The Safety and Efficacy of Oral Vitamin C Administration on Erythropoietin Dosing Requirement in End-Stage Renal Disease Patients on Regular Hemodialysis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aimed to evaluate the safety and efficacy of oral vitamin C administration on erythropoietin dosing requirement in end-stage renal disease patients on regular hemodialysis.

Detailed description

Erythropoietin deficiency is the most significant cause of anemia in chronic kidney disease (CKD) and has been demonstrated to occur at each stage of kidney failure. Because the kidney is the sole source of erythropoietin (EPO) synthesis in adults, reduction in kidney mass as occurs in progressive CKD often results in impairment of EPO production, resulting in anemia. Vitamin C deficiency can interfere with iron absorption and utilization, as well as lead to various abnormalities. The occurrence of widespread vitamin C deficiency in dialysis patients calls for greater attention to these clinical problems. Ascorbic acid is low in patients with advanced CKD and end-stage renal disease (ESRD) due to dietary restrictions on vitamin C-rich foods, as these foods are usually also rich in potassium.

Conditions

• Vitamin C
• Oral Administration
• Erythropoietin
• End-Stage Renal Disease
• Regular Hemodialysis

Interventions

Type	Name	Description
DRUG	Normal regimen of treatment of anemia	Patients were on normal regimen of treatment of anemia.
DRUG	Vitamin C	Patients were on 250 mg oral vitamin C daily for 3 months.
DRUG	Vitamin C	Patients were on 500 mg oral vitamin C daily for 3 months.

Timeline

• Start date: 2019-08-01
• Primary completion: 2024-04-28
• Completion: 2024-04-28
• First posted: 2025-07-21
• Last updated: 2025-12-18

Locations

1 site across 1 country: Egypt