NCT07074795

Use of Nitrous Oxide During Office Hysteroscopy

Nitrous Oxide During Office Hysteroscopy for Reducing Pain and Anxiety

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Maaynei Hayesha Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: * Does it reduce pain during the procedure? * Does it increase the success rate? * Does it improve patient satisfaction? * Does it reduce anxiety? * Which populations benefit more (e.g., parity, menopausal status, number of previous surgeries, type and duration of procedure, and type of device)? Participants will be asked about their pain levels during the procedure, as well as their anxiety levels. All responses will be recorded. Written informed consent will be obtained prior to initiation.

Detailed description

Office hysteroscopy offers a convenient alternative to operating room-based procedures, yet many patients experience pain and anxiety significant enough to interfere with procedural completion. Nitrous oxide is a fast-acting inhaled agent with both analgesic and anxiolytic properties, widely used in outpatient settings across various medical specialties. This study will investigate the role of nitrous oxide in improving patient tolerability and comfort during office hysteroscopy. Participants will undergo a standardized procedural protocol with either nitrous oxide or ambient air administered via a demand-valve mask system. Comprehensive data on patient responses during the procedure will be collected and analyzed. The study will also examine variability in patient responses across different subgroups and procedural types. All procedures will adhere to ethical standards, and patient confidentiality will be maintained throughout.

Conditions

• Abnormal Uterine Bleeding
• Postmenopausal Bleeding
• Endometrial Polyps
• Retained Products of Conception
• Uterine Fibroids
• Intrauterine Adhesions

Interventions

Type	Name	Description
PROCEDURE	Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy	Inhaled nitrous oxide
PROCEDURE	inhalation of ambient air during office hysteroscopy	inhalation of ambient air

Timeline

• Start date: 2025-07-01
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2025-07-20
• Last updated: 2025-07-20

Locations

1 site across 1 country: Israel