Trials / Completed
CompletedNCT07074652
The Effect of SSRIs on Threat of Shock Potentiated Neural Circuitry
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 145 (actual)
- Sponsor
- UCLH/UCL Joint Research Office · Academic / Other
- Sex
- All
- Age
- 18 Years – 50 Years
- Healthy volunteers
- Accepted
Summary
This study aims to increase the knowledge about psychological processes which may contribute to mental health problems such as depression and anxiety. This study aims to investigate if administering Escitalopram, an antidepressant which increases serotonin levels in parts of the brain, affects how the brain processes emotional information. It is hoped that measuring these changes will increase the understanding of processes involved in mental health problems.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Escitalopram | Participants received 2-3 weeks of escitalopram. |
| DRUG | Placebo | Participants received 2-3 weeks of placebo, matched in colour and size to the escitalopram. |
Timeline
- Start date
- 2017-12-01
- Primary completion
- 2022-06-30
- Completion
- 2022-06-30
- First posted
- 2025-07-20
- Last updated
- 2025-07-20
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT07074652. Inclusion in this directory is not an endorsement.