NCT07073716

TAC, SOD and MDA Responses to Aerobic Exercise Versus Phoenix Seed in Obese Sedentary Females

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: 35 Years – 55 Years
• Healthy volunteers: Accepted

Summary

the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. • All subjects will follow the given instructions strictly during the study duration, regarding the assessment and the treatment procedure, all participants will be evaluated under the same environmental conditions

Detailed description

reactive oxygen species (ROS) are generated as metabolic by-products by biological systems during Processes like protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. When ROS production increases, they start showing harmful effects on important cellular structures like proteins, lipids, and nucleic acids. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance in the onset and/or progression of several diseases as cancer, diabetes, metabolic disorders, atherosclerosis, and cardiovascular diseases. Date seed is a waste product that is high in polyphenolics (a mjor antioxidant compounds), phenolicacid (allergic, epicatechin, catechol,chlorogenic), carotenoids, total dietary fiber (such as pectin, β-glucan, and arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements Phytosterols as β-sitosterol, campesterol, and Δ5-avenasterol are The major components of date seed oil sterols (contents varied between 4.70 and 8.45 mg/g) are important micronutrients and essential structural components of the cellular membrane.they serve crucial functions, such as modulating membrane permeability and fluidity, antioxidant activity , cholesterol-lowering effects and anti-inflammatory properties in addition to their putative contribution to reducing the risk of cardiovascular diseases and affording benefits to the immune system. Physical activity improves antioxidant defences, lowers lipid peroxidation levels and involved in the protection from cardiovascular disorders, type II diabetes, metabolic syndrome and neurodegenerative diseases like Alzheimer's disease both in adult and in aged individuals. Thus emphasizing the importance of regular physical activity to decelerate the aging-associated impairment process. Myokines,the bioactive peptides released by skeletal muscle following exercise as acrucial regulator of metabolic and protective pathways in peripheral tissues, particularly in combating oxidative stress and inflammation through activating intracellular signalling pathways within the liver that are involved in the liver's antioxidant defences. this study aims to compare between aerobic exercise and phoenix seed in their antioxidant potential.

Conditions

• Aerobic Exercise Phoenix Seed, Antioxidant Potential

Interventions

Type	Name	Description
OTHER	aerobic exercise	the exercise protocol was applied following these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training.
DIETARY_SUPPLEMENT	phoenix seed	consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day
COMBINATION_PRODUCT	aerobic exercise+ phoenix seed	a specialized programme of aerobic exercise.the exercise protocol follow these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training. the specialized program of phoenix seed consumption (consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day)

Timeline

• Start date: 2025-07-10
• Primary completion: 2025-10-10
• Completion: 2025-11-10
• First posted: 2025-07-18
• Last updated: 2025-07-18