Trials / Completed
CompletedNCT07073157
Effect of HRS-8427 for Injection on the Pharmacokinetics of Furosemide and Metformin in Healthy Subjects。
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 24 (actual)
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd. · Industry
- Sex
- All
- Age
- 18 Years – 45 Years
- Healthy volunteers
- Accepted
Summary
The pharmacokinetics of HRS-8427 for injection on the transporter OAT1 substrate furosemide and the MATE1/METE2-K substrate metformin were evaluated in healthy subjects. The safety of HRS-8427 for injection was evaluated in combination with furosemide and metformin.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | HRS-8427 injection plus furosemide | HRS-8427 injection plus furosemide |
| DRUG | HRS-8427 injection plus metformin | HRS-8427 injection plus metformin |
Timeline
- Start date
- 2025-07-15
- Primary completion
- 2025-08-15
- Completion
- 2025-08-15
- First posted
- 2025-07-18
- Last updated
- 2025-08-28
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT07073157. Inclusion in this directory is not an endorsement.