NCT07072975

CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 40 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses. this randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed. Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.

Conditions

• Intermittent Hypoxia
• Exercise Recovery
• Intermittent Exercise
• Rating Exertion Perception
• Sleep

Interventions

Type	Name	Description
OTHER	Normobaric hypoxia	Normobaric hypoxia (inspired oxygen fraction of 12.9%) applied between-sets recovery periods
OTHER	normoxic condition	Between-sets recovery periods under normoxic condition

Timeline

• Start date: 2025-10-01
• Primary completion: 2027-07-01
• Completion: 2027-08-01
• First posted: 2025-07-18
• Last updated: 2025-10-01

Locations

1 site across 1 country: France