NCT07072546

Chitosan and i-PRF in Palatal Wound Healing

Effects of Chitosan and i-PRF on Wound Healing After Palatal Graft Harvesting

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Biruni University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effects of chitosan and injectable platelet-rich fibrin (i-PRF) on wound healing at the donor site following free gingival graft (FGG) procedures. The palatal donor area often experiences delayed healing and postoperative discomfort, motivating the search for effective biomaterials to enhance recovery and reduce patient morbidity. Although various approaches have been investigated, the combined application of chitosan and i-PRF has not yet been explored in this context. The study examines three patient groups treated at the periodontology departments of Çukurova and Biruni University: one with gelatin sponge (control), one with chitosan, and one with chitosan infused with i-PRF. Parameters such as pain (VAS), bleeding, burning sensation, dietary changes, epithelialization (PEHI score), and color match were assessed over a 2-month follow-up. The findings are expected to provide insights into whether i-PRF-enhanced chitosan offers superior healing outcomes and greater patient comfort compared to conventional methods.

Conditions

• Free Gingival Graft
• Wound Healing
• i-PRF
• Chitosan

Interventions

Type	Name	Description
PROCEDURE	free gingival graft + gelatin sponge	Free gingival graft surgery and application of gelatin sponge to the palatal wound
PROCEDURE	free gingival graft + chitosan	free gingival graft surgery and application of chitosan to the palatal wound
PROCEDURE	free gingival graft + chitosan and i-PRF	free gingival graft surgery and application of chitosan and i-PRF to the palatal wound

Timeline

• Start date: 2025-07-12
• Primary completion: 2025-12-10
• Completion: 2025-12-10
• First posted: 2025-07-18
• Last updated: 2026-01-27

Locations

2 sites across 1 country: Turkey (Türkiye)