NCT07071467

Testing Sodium Hypochlorite and Hyaluronic Acid as an Adjunct to Non-Invasive Therapy for Stage III Periodontitis Management

Innovative Clean-Seal Technique Incorporating Sodium Hypochlorite and Hyaluronic Acid as an Adjunct to Non-Invasive Therapy for Stage III Periodontitis Management

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Karim Ismail · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The study was designed to evaluate the concept of the clean \& seal, using sodium hypochlorite gel and hyaluronic acid as adjunctive to non-surgical therapy for management of Stage III Periodontitis.

Conditions

• Periodontitis (Stage 3)
• Periodontitis

Interventions

Type	Name	Description
OTHER	Scaling and root planing with sodium hypochlorite and hyaluronic acid	Sodium hypochlorite gel was applied first for 30 seconds, then followed by subgingival instrumentation of the site. Then, 1.8% hyaluronic acid (1.6% cross-linked, 0.2% natural hyaluronic acid ) was applied subgingivally into the periodontal pocket to seal the site.
PROCEDURE	Scaling and root planing	Pockets were treated with sub-gingival scalling and root planning alone.

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-01-10
• Completion: 2024-01-10
• First posted: 2025-07-17
• Last updated: 2025-07-17

Locations

1 site across 1 country: Egypt