NCT07069478

Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 125 (estimated)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 21 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

Conditions

• CBD
• Cannabidiol
• Stress
• Acute Stress Reaction

Interventions

Type	Name	Description
OTHER	Stress Intervention	Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.

Timeline

• Start date: 2025-06-01
• Primary completion: 2026-11-30
• Completion: 2026-11-30
• First posted: 2025-07-16
• Last updated: 2025-07-16

Locations

1 site across 1 country: United States