NCT07068282

The Effect of Novel D3 Use as a Mouthwash in COVID-19 Patients

Vitamin D3, Mouthwash, Saliva Testing, Covid-19, Antiviral Testing

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: King Faisal Specialist Hospital & Research Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The PI's goal of this \[interventional/clinical trial\] is to \[explore the antiviral properties of vitamin D3 on saliva samples collected before and after the use of a vitamin D3 mouthwash\] in \[ adult participants, both genders, with COVID-19 who tested positive on a swab test\]. The main question\[s\] aims to answer \[is\]: \[Assess the antiviral potential of a novel vitamin D-based mouthwash in COVID-19-positive participants\]. PI will compare both \[Control group: saliva only- before use of mouthwash\], and the \[study group: after use of the mouthwash in saliva\] to see if there is \[any veridical effect present in saliva after running lab tests\]. Participants will \[self-collect saliva in a given tube (color coded orange), then 10-15 minutes later or more, participants will swish with D3 mouthwash, and will give another sample \[saliva + mouthwash\] in another (green labeled tube). For each participant, each of the following will be given: * 2 collecting tubes: orange labeled tube (for saliva collection only) and green labeled tube (for saliva collection after mouthwash use). * The vial containing vitamin D3 mouthwash.

Detailed description

Twenty-five adult participants confirmed COVID-19-positive, via rapid antigen testing (RAT) thru nasal swabs (NS), followed by saliva samples collected before and after using a vitamin D3 mouthwash. Samples were analyzed using RAT and rapid polymerase chain reaction (R-PCR) to measure viral load.

Conditions

• Corona Virus Disease 19 (COVID-19)

Interventions

Type	Name	Description
DRUG	Cholecalciferol (vitaminD3)	Vitamin D3 mouthwash was prepared for COVID-19 participants, to compare between the saliva only (control group), and with the use of mouthwash in saliva after the participants swish for 60 seconds (experimental group) and compare the effect of vitamin D over the virus in saliva, from both groups by testing via RAT and R-PCR.

Timeline

• Start date: 2024-07-24
• Primary completion: 2025-01-25
• Completion: 2025-02-12
• First posted: 2025-07-16
• Last updated: 2025-07-16

Locations

1 site across 1 country: Saudi Arabia