NCT07067632

To Study the Mortality Outcome of Controlled Blood Pressure Participants

Mortality Outcome of Controlled Hypertension in Randomized Controlled or Open-label Study Intentionally Directed Intervention Effect Blood Pressure: A Systematic Review and Meta-Analysis

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: DejthidaNathaphong · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials. To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

Detailed description

Sensitivity Analyses Excluding high-risk of bias studies Excluding short follow-up (\<1 year)

Conditions

• Valid MeSH Conditions
• Hypertension (HTN)

Interventions

Type	Name	Description
DRUG	Antihypertensive treatment	Any intervention (pharmacological, device-based, lifestyle) intentionally directed at lowering BP Control groups receiving placebo, standard of care, or no intervention

Timeline

• Start date: 2025-07-01
• Primary completion: 2026-12-31
• Completion: 2027-02-01
• First posted: 2025-07-16
• Last updated: 2026-04-13

Locations

1 site across 1 country: Thailand