NCT07067099

Neutralizing Interferon Type 1 in Hidradenitis Suppurativa

Use of Plasma With Neutralizing Autoantibodies to Type I Interferons in Patients With Severe Refractory Flare-up of Hidradenitis Suppurativa

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 6 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to evaluate the safety and type 1 Interferon (IFN) neutralization in patients with refractory severe Hidradenitis Suppurativa (Hurley stage III) after transfusion of plasma containing high titer anti-IFN-1 autoantibodies.

Conditions

• Hidradenitis Suppurativa (HS)

Interventions

Type	Name	Description
BIOLOGICAL	Plasma with neutralizing autoantibodies to Type I Interferons	Transfusion of one unit of plasma containing high titre anti-IFN-1 autoantibodies

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-06-01
• Completion: 2026-09-01
• First posted: 2025-07-16
• Last updated: 2025-07-16

Locations

1 site across 1 country: France