NCT07065604

Tubeless VATS for Mediastinal Neoplasm

A Randomized Controlled Trial of Non-intubated Versus Intubated VATS for Mediastinal Neoplasm

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 132 (estimated)
• Sponsor: Shuben Li · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

In recent year, non-intubated anesthesia had emerged as an available and promising alternative for thoracic procedure. However, its safety and feasibility in video-assisted thoracoscopic surgery (VATS) for mediastinal neoplasm remain controversial. This randomized controlled trial is designed to evaluate the impact of the non-intubated approach on surgical and perioperative outcomes in patients undergoing mediastinal neoplasm resection.

Detailed description

Non-intubated anesthesia has gained widespread adoption in recent years, representing a significant advancement in both thoracic surgery and anesthetic practice. The surgical safety and feasibility of tubeless VATS for mediastinal neoplasm has been confirmed. However, the oncological long-term outcomes of RATS lobectomy has not been studied by randomized controlled trial. Accordingly, this randomized controlled trial aims to evaluate whether the non-intubated approach provides comparable short-term and long-term outcomes to the conventional intubated technique in VATS for mediastinal neoplasm resection.

Conditions

• Mediastinal Neoplasm
• VATS
• Tubeless
• Non-intubated Anesthesia

Interventions

Type	Name	Description
PROCEDURE	Non-intubated VATS for mediastinal neoplasm	Non-intubated VATS for mediastinal neoplasm
PROCEDURE	Intubated VATS for mediastinal neoplasm	Intubated VATS for mediastinal neoplasm

Timeline

• Start date: 2025-03-26
• Primary completion: 2028-05-01
• Completion: 2028-08-31
• First posted: 2025-07-15
• Last updated: 2025-07-15

Locations

1 site across 1 country: China