NCT07065383

Rebalancing the Fat Content of the Heart and Muscles

Intramyocellular Lipid Compartments After Glucagon-like Peptide 1 Receptor Agonist Therapy in Type 2 Diabetes - Rebalancing the Fat Content of the Heart and Muscles

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Aberdeen · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Traditional diabetes therapies focus on improving blood sugar control. However, many studies show that this may not be enough. New treatments focusing on weight loss have heralded better results. One of these treatments is Semaglutide and the investigators wish to examine its effects further in this study. The investigators propose to investigate what happens to the fat inside the heart and the leg muscles.

Detailed description

Traditionally, diabetes therapies focus on improving glycaemic control. However, decades of well conducted clinical trials showed that glycaemic control alone has failed to reduce both all-cause and cardiovascular mortality in diabetes patients. The new diabetes treatment strategies of combining glucose control with weight reduction have heralded better cardiovascular outcomes, however their follow-up has been relatively short-term. The investigators propose to explore the effects of semaglutide administration plus dietary counselling and physical activity encouragement versus a more intensive strategy of semaglutide administration plus a personalised and supervised program of resistance and endurance exercise training.

Conditions

• Diabetes Mellitus Type 2

Interventions

Type	Name	Description
DRUG	Semaglutide administration plus dietary counselling and physical activity encouragement	Semaglutide administration plus dietary counselling and physical activity encouragement
DRUG	Semaglutide plus a personalised and supervised program of resistance and endurance training	Semaglutide administration plus a personalised and supervised program of resistance and endurance training.

Timeline

• Start date: 2025-08-01
• Primary completion: 2028-07-31
• Completion: 2028-07-31
• First posted: 2025-07-15
• Last updated: 2025-07-15