NCT07064642

NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison

A Retrospective Comparison Of The Effects Of Low-Flow And High-Flow Anesthesia On Hemodynamics, Neutrophil-To-Lymphocyte Ratio, And Postoperative Outcomes In Tympanoplasty And Myringoplasty Surgeries

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: Eda KAZANÇ ÖZDEN · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between \[September 1, 2022\] and \[April 1, 2023\]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.

Detailed description

This study investigates the influence of anesthetic gas flow rates on systemic inflammation and hemodynamic stability in middle ear surgeries. While low-flow anesthesia is associated with reduced environmental exposure and cost-effectiveness, its impact on inflammatory markers and recovery outcomes remains less clearly defined. The neutrophil-to-lymphocyte ratio (NLR) is used as a readily available, cost-effective biomarker of systemic inflammation. This study retrospectively analyzes perioperative data from patients who underwent tympanoplasty or myringoplasty, comparing NLR levels, intraoperative vital signs, and postoperative recovery parameters between low-flow and high-flow anesthesia groups. The results may contribute to optimizing anesthetic strategies in otologic surgeries, with emphasis on inflammation modulation and patient safety.

Conditions

• Tympanoplasty
• Myringoplasty
• Neutrophil-to-Lymphocyte Ratio
• Low-flow Anesthesia
• High-flow Anesthesia

Timeline

• Start date: 2023-07-20
• Primary completion: 2023-08-20
• Completion: 2023-09-20
• First posted: 2025-07-15
• Last updated: 2025-07-17

Locations

1 site across 1 country: Turkey (Türkiye)