NCT07064512

The Effect of Heat Exposure on Physiological Markers

The Effect of Exertional and Exogenous Heating on Physiological Markers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Lithuanian Sports University · Academic / Other
• Sex: Male
• Age: 18 Years – 36 Years
• Healthy volunteers: Accepted

Summary

This study is the first to examine the effects of core temperature elevation on kynurenine pathway (KP) metabolites in healthy young males. It was hypothesized that rise in core temperature due to both pasive heating and exercise will initiate a stress response, affecting the concentration of KP metabolites. Additionally, it was expected that the exercise would produce more pronounced effects due to the increased cardiovascular, mechanical, and metabolic demands associated with it. Thus, the the main purpose of the present study was to investigate and to compare the effects of two distinct heat stress modalities on KP metabolites.

Conditions

• Healthy Adult Male

Interventions

Type	Name	Description
OTHER	Endogenous heating	Exercise was used as the endogenous heating modality, the participant cycled at 60% of his VO2max until rectal temperature reached 39°C
OTHER	Exogenous heating	Hot-water immersion was used as the exogenous heating modality, where the participants sat immersed in a water bath at 43.5 ± 0.5°C and remained submerged until rectal temperature reached 39°C.

Timeline

• Start date: 2021-01-11
• Primary completion: 2021-03-12
• Completion: 2021-03-12
• First posted: 2025-07-14
• Last updated: 2025-07-17

Locations

1 site across 1 country: Lithuania