NCT07063732

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

The Effect of Ketone Monoester Supplementation and High Altitude on Exercising Cerebral Blood Flow

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Conditions

• High Altitude Hypoxia
• Exercise

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone Monoester (KME)	0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
DIETARY_SUPPLEMENT	Placebo	Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement

Timeline

• Start date: 2025-05-28
• Primary completion: 2025-08-31
• Completion: 2025-08-31
• First posted: 2025-07-14
• Last updated: 2025-07-14

Locations

2 sites across 2 countries: United States, Canada