NCT07063628

Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity

Comparative Assessment of Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity: Insights From Gensini Scoring

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 508 (actual)
• Sponsor: Damanhour University · Academic / Other
• Sex: All
• Age: 38 Years – 80 Years
• Healthy volunteers: —

Summary

Our study specifically will address the value of modified triglyceride glucose indices versus left ventricular speckle tracking in prediction of severity of coronary artery disease assessed by Gensini score.

Detailed description

A cross sectional study that will be conducted in Cardiovascular Department of Tanta University in Egypt in the period from May to July 2025 . Two hundred patients diagnosed with coronary artery diseases were included in the study. Patients were considered to have confirmed coronary artery disease through angiographically proven CAD. Provision of privacy: Privacy of all data is guaranteed and there will be a code number for every patient and include all of his or her investigations. Informed consent: Informed written consent will be obtained from all patients after full explanation of benefits and risks of the study. Methods: Study patients and procedures: Selection criteria included any patient with chronic stable angina and proved coronary artery disease by coronary angiography Exclusion criteria included: Any patients with acute coronary syndrome, arrhythmias, previous Percutaneous coronary intervention (PCI) or Coronary Artery Bypass Graft (CABG) surgery All the participants were subjected to following: 1. History taking for presence of risk factors of cardio vascular disease as age, sex, smoking, physical inactivity, diabetes and hypertension. 2. Physical examination including height, weight and waste circumference 3. Resing 12 leads ECG 4. Laboratory investigations: * Fasting blood glucose (FBG) * Triglyceride (TG), TG index. * Total Cholesterol level * Renal Function test . Echocardiographic evaluation 6\. Coronary angiography 7. Gensini score calculated by summation of the individual coronary segment scores.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	TyG-derived index.	Derived indices included: * Ty,G×B,M,I = TyG index × body mass index * TyG×W,C = TyG index × waist circumference * TyG×WH,tR = TyG index × waist-to-height ratio Quartile-based stratification was applied to each TyG-derived index.
DIAGNOSTIC_TEST	Left Ventricular Speckle Tracking	Coronary Angiography and Gensini Scoring: All participants underwent standard diagnostic coronary angiography. CAD was categorized as one-, two-, or three-vessel disease based on the number of vessels with ≥50% stenosis. The severity of CAD was quantified using the Gensini score, which assigns a severity weight to each lesion depending on degree of stenosis and anatomical location. Final scores were calculated by summing weighted values across all coronary segments.

Timeline

• Start date: 2025-04-30
• Primary completion: 2025-07-01
• Completion: 2025-07-03
• First posted: 2025-07-14
• Last updated: 2025-07-16

Locations

1 site across 1 country: Egypt