NCT07063264

Effects of HD-tDCS During Slow-wave Sleep on Associative Memory

Effects of High-definition Transcranial Direct Current Stimulation During Slow-wave Sleep on Associative Memory

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 87 (actual)
• Sponsor: WANG KAI · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

To evaluate the effects of afternoon naps and high-definition transcranial direct current stimulation (HD-tDCS) over the left dorsolateral prefrontal cortex (DLPFC) in associative memory (AM)

Detailed description

Healthy adults will be randomized into three groups: a sleep with active stimulation (Sleep-A) group will receive active anode HD-tDCS during slow-wave sleep (SWS) of non-rapid eye movement sleep (NREM) at afternoon nap, a sleep with sham stimulation (Sleep-S) group will receive afternoon nap with sham stimulation, and wake with active stimulation (Wake-A) group will receive active anode HD-tDCS during wakefulness. An anode stimulation electrode will be placed in F3 (10/20 system) which intend to target the left DLPFC, and four cathodes will be placed at FCz, AFz, F7, and C5 (10/20 system). The face-word AM task and other multidimensional neuropsychological tasks will be performed before and after afternoon napping.

Conditions

• Transcranial Direct Current Stimulation
• Healthy Adults

Interventions

Type	Name	Description
DEVICE	high-definition transcranial direct current stimulation (HD-tDCS)	HD-tDCS is described as a non-invasive form of brain stimulation that uses a low-intensity, direct current applied directly to the head through scalp electrodes
DEVICE	sham high-definition transcranial direct current stimulation (HD-tDCS)	Sham HD-tDCS was delivered using the same protocol and current intensity, but the period of active stimulation was only during the ramp-up and ramp-down periods of 30 and 30 seconds.

Timeline

• Start date: 2022-01-12
• Primary completion: 2023-02-20
• Completion: 2023-08-23
• First posted: 2025-07-14
• Last updated: 2025-07-14

Locations

1 site across 1 country: China