NCT07062016

Molecular and ctDNA Characterization of High-Risk Endometrial Cancer

MC230601 Molecular and ctDNA Characterization of High-Risk Endometrial Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study seeks to better understand the recurrence of high-risk endometrial cancer. It will collect information about cancer genetics to find out various hereditary or cancer specific genetic variants that may have a role in diagnosis or management and prognosis of cancer. It also seeks to develop a genetic results and medical record databank for future studies.

Detailed description

PRIMARY OBJECTIVE: I. To generate preliminary data for a risk stratification model for recurrence including traditional histopathologic risk factors, molecular characterization in endometrial cancer patients with features of aggressive disease. OUTLINE: This is an observational study. Patients undergo blood and tissue sample collection and have their medical records reviewed throughout the study.

Conditions

• Endometrial Carcinoma
• Endometrial High Grade Endometrioid Adenocarcinoma
• Stage II Endometrial Cancer
• Stage III Endometrial Cancer
• Stage IV Endometrial Cancer

Interventions

Type	Name	Description
OTHER	Non-Interventional Study	Non-interventional study

Timeline

• Start date: 2025-10-01
• Primary completion: 2028-10-31
• Completion: 2028-10-31
• First posted: 2025-07-14
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States