NCT07061496

Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults

Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults: A Community-Based, Open-Label, Randomized Trial in a Low-Resource Setting

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 226 (estimated)
• Sponsor: Umair Ali · Other Government
• Sex: All
• Age: 18 Years – 59 Years
• Healthy volunteers: Not accepted

Summary

This study is being done to compare the effect of regular exercise and metformin in people who have prediabetes. It is a community-based, open-label, randomized trial in which eligible participants will be divided into two groups. One group will do moderate physical exercise, and the other group will take metformin for 12 weeks. We will check their fasting blood sugar and HbA1c before and after the treatment to see which method works better for controlling sugar levels. The study is being done in a low-resource community setup to see which option is more practical and effective in real-life Pakistani settings.

Conditions

• Pre Diabetic
• Pre Diabetes

Interventions

Type	Name	Description
BEHAVIORAL	Moderately intense exercise	Structured moderate-intensity aerobic activity (e.g., brisk walking) for 30-45 minutes/day, 5 days/week, for 12 weeks.
DRUG	MetFORMIN 500 Mg Oral Tablet	Participants will receive oral metformin 500 mg twice daily for 12 weeks.

Timeline

• Start date: 2025-08-10
• Primary completion: 2026-02-15
• Completion: 2026-03-15
• First posted: 2025-07-11
• Last updated: 2025-07-23

Locations

1 site across 1 country: Pakistan