NCT07060300

Comprehensive Assessment of Reactions to Pharmacogenetics in Complex Care Patients

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Children's Hospital Medical Center, Cincinnati · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to determine the feasibility and acceptability of Pharmacogenetic Testing, and the attitudes towards the same in caregivers of complex care patients in Cincinnati, OH. The main question\[s\] it aims to answer are: 1. With financial and access barriers removed, do caregivers of complex care patients agree to receive Pharmacogenetic testing for their children? 2. With financial and access barriers removed, what are some remaining barriers to implementation of pharmacogenetics testing? 3. What are the prevailing attitudes towards Pharmacogenetic testing in the complex care population? Participants will be offered pharmacogenetic testing for their child free of charge, and will be asked to fill out a voluntary survey. Certain caregivers of complex care patients may be asked if they want to participate in a short semi-structured interview.

Detailed description

Through this research, the investigators expect to have successfully provided pharmacogenetic testing to a large cohort of patients in Cincinnati Children's Complex Care Clinic, allowing for an improved understanding of how to provide pharmacogenetic testing in children with medical complexity (feasibility) and of caregiver attitudes about pharmacogenetic testing for their children (acceptability). The knowledge gained from this study will be used to inform future program implementations in children with medical complexity (CMC) populations. Successfully tested patients will also provide for future studies to measure the effectiveness of pharmacogenetic testing in this population, as well as prescriber behavior when provided pharmacogenetic testing results.

Conditions

• Pediatric Medical Complexity Based on PMCA Score of 3

Interventions

Type	Name	Description
OTHER	Agree to Pharmacogenetic Testing	Caregivers agree to receive pharmacogenetic testing for their child.

Timeline

• Start date: 2025-07-15
• Primary completion: 2027-06-30
• Completion: 2028-06-30
• First posted: 2025-07-11
• Last updated: 2025-07-24

Locations

1 site across 1 country: United States