NCT07060144

Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Texas at Austin · Academic / Other
• Sex: Female
• Age: 18 Years – 46 Years
• Healthy volunteers: Not accepted

Summary

Pregnant women with a primary diagnosis of posttraumatic stress disorder (PTSD) (PTSD Checklist for DSM-5 (PCL-5) score \> 33) will be randomized to receive conventional cognitive processing therapy (CPT) (60-min session once/week for 12 weeks) or massed CPT (mCPT) (an intensive schedule of 12 60-min sessions over 5 days, approximately 2-3 sessions per day) via telemedicine, for treatment of PTSD. The research aims will be three-fold: (1) Evaluate the relative efficacy and tolerability of CPT vs. mCPT for treatment of perinatal PTSD and depression; (2) Determine the effect of CPT upon maternal-infant attachment and interaction; (3) Collect pilot data of obstetric and neonatal outcomes among those receiving the two CPT delivery schedules.

Conditions

• Posttraumatic Stress Disorder (PTSD)
• Pregnancy

Interventions

Type	Name	Description
BEHAVIORAL	Regular CPT	Standard-model Cognitive Processing Therapy (CPT) - one 60-min session per week for 12 weeks total
BEHAVIORAL	Massed CPT	Massed CPT - two 60-min sessions each day for 5 consecutive days (10 sessions total)

Timeline

• Start date: 2025-07-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2025-07-11
• Last updated: 2025-07-11

Locations

1 site across 1 country: United States