NCT07058415

Impact of Three Probabilistic Antibiotic Therapy on Digestive Microbiota and Colonization With Multi-resistant Bacteria

Osteoarticular Infections on Equipment: Impact of Three Probabilistic Antibiotic Therapy on Digestive Microbiota and Colonization With Multi-resistant Bacteria

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In the event of suspected osteoarticular material infection (OAMI), broad-spectrum probabilistic antibiotic therapy is recommended immediately after revision surgery. There are no efficacy data to suggest that any particular to favour any particular molecule. However, the choice may depend on the impact on the microbiota and on Enterobacteriaceae colonization with multi-resistant Enterobacteriaceae. Our aim is to evaluate three different strategies efepime+daptomycin C+D, piperacillin-tazobactam+daptomycin (PT+D) and ceftobiprole (CFB).

Conditions

• Osteoarticular Material Infection

Interventions

Type	Name	Description
OTHER	Stool sample 1	Stool sampling at D0 for having baseline reference
OTHER	Stool sample 2	Stool sampling at D5 to study the impact of antibiotics on microbiota
OTHER	Stool sample 3	Stool sampling at DX+28 to study the impact of antibiotics on microbiota

Timeline

• Start date: 2025-09-01
• Primary completion: 2027-05-01
• Completion: 2027-05-01
• First posted: 2025-07-10
• Last updated: 2025-07-10

Locations

4 sites across 1 country: France