NCT07058324

The Effects of Chicory Root-derived Prebiotic on Mood and Stress Responsiveness in Healthy Adults With Mild to Moderate Levels of Stress and Anxiety

The Effects of Chicory Root-derived Prebiotic on Mood and Stress Responsiveness in Healthy Adults With Mild to Moderate Levels of Stress and Anxiety: a Randomized, Placebo-controlled, Double-blind, Monocentric, Two-armed Parallel, Prospective Study - The PRIME Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 204 (estimated)
• Sponsor: Beneo-Institute · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Emerging evidence from preclinical research suggests that prebiotic fibres may play a beneficial role in supporting mental health through modulation of the gut-brain axis-a complex communication network linking the gastrointestinal tract and the central nervous system. Chicory root-derived prebiotic fibre, already well-established for its positive effects on glycaemic control and bowel regularity, has recently shown promise in this context. The present study aims to investigate the mental health benefits of chicory root fibre in a larger and more diverse population, thereby contributing to the growing body of evidence supporting nutritional strategies for mental well-being.

Conditions

• Stress
• Healthy Subjects
• Anxiety, Mild to Moderate

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Prebiotic fiber	Chicory root-derived prebiotic fiber
DIETARY_SUPPLEMENT	Placebo control	Maltodextrin

Timeline

• Start date: 2025-06-02
• Primary completion: 2026-06-01
• Completion: 2026-08-01
• First posted: 2025-07-10
• Last updated: 2025-08-07

Locations

1 site across 1 country: Germany