NCT07057141

Biomimetic Hydroxyapatite Toothpaste and Mouthwash for Reducing Dental Sensitivity

Effect of Biomimetic Hydroxyapatite-Based Toothpaste and Mouthwash on Dental Sensitivity in Patients With Gingival Recession: A Randomized Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: University of Pavia · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This randomized controlled clinical trial evaluates the effectiveness of a biomimetic hydroxyapatite-based toothpaste and mouthwash in reducing dental sensitivity in patients with gingival recession. A total of 100 participants will be randomly assigned to two groups. The control group will receive Biorepair Total Protection toothpaste, and the trial group will receive Biorepair high-density mouthwash. Both products will be applied for 30 seconds. Dental sensitivity will be assessed before and after treatment using the Shiff Air Index and the Visual Analogue Scale (VAS).

Conditions

• Tooth Sensitivity
• Gingival Recession Generalized Moderate
• Gingival Recession Localized Moderate

Interventions

Type	Name	Description
DEVICE	Biorepair Total Protection Toothpaste	Application of Biorepair Total Protection toothpaste for 30 seconds, performed once in a clinical setting. The aim is to reduce dental sensitivity in patients with gingival recession.
DEVICE	Biorepair High-Density Mouthwash	Application of Biorepair High-Density mouthwash for 30 seconds, performed once in a clinical setting. The aim is to reduce dental sensitivity in patients with gingival recession.

Timeline

• Start date: 2025-07-15
• Primary completion: 2025-09-05
• Completion: 2025-09-15
• First posted: 2025-07-09
• Last updated: 2025-09-17

Locations

1 site across 1 country: Italy