NCT07055009

Multi-centred Clinico-genetic Study of Actinic Prurigo in Thailand

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 47 (estimated)
• Sponsor: Chulalongkorn University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This research project investigates the clinical and genetic associations of Actinic Prurigo (AP) in the Thai population. As a rare chronic photodermatosis, AP has been observed to occur more frequently in individuals with certain genetic predispositions, particularly specific Human Leukocyte Antigen (HLA) types. Previous studies have suggested variations in clinical presentation and HLA allele distributions between Asian and Western populations. The primary aim is to explore the relationship between clinical manifestations of AP and genetic profiles, including HLA typing, among Thai individuals. Additionally, the study seeks to examine whether different HLA types are associated with varying responses to treatment. The study design is a cross-sectional comparative study, involving both AP patients and age-matched healthy controls. Given the rarity of the condition, patient recruitment will be conducted across four collaborating institutions: King Chulalongkorn Memorial Hospital Siriraj Hospital Institute of Dermatology

Conditions

• Actinic Prurigo

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Targeted long-read HLA sequencing	Genetic study
OTHER	RNA extraction	Nanostring technology, Seattle
OTHER	Full Skin examination	Skin and mucosa examination

Timeline

• Start date: 2025-03-30
• Primary completion: 2026-05-31
• Completion: 2026-12-31
• First posted: 2025-07-08
• Last updated: 2025-07-08

Locations

1 site across 1 country: Thailand