NCT07054424

Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke Rehabilitation

Development of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined With Machine-assisted Bimanual Therapy (BT) in Upper Limb Rehabilitation

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (estimated)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients. The participants will be individuals aged 40-80 years who have experienced a first-time ischemic or hemorrhagic stroke. The main questions it aims to answer are: * Does the combined therapy enhance motor recovery compared to traditional rehabilitation methods? * Are changes in brain activity associated with improvements in upper limb function? Participants will be randomly assigned to different groups and will: * Receive rTMS stimulation on specific areas of the brain to modulate neural activity, * Perform machine-assisted bimanual exercises to promote motor skills, and * Undergo assessments before, immediately after, and during follow-up periods to measure functional improvements.

Conditions

• Post-stroke Upper Limb Hemiparesis
• Repetitive Transcranial Magnetic Stimulation (rTMS)
• Bimanual Therapy
• Neuromodulation

Interventions

Type	Name	Description
OTHER	Conventional occupation therapy	Standard occupational therapy focused on improving daily functional skills through task-specific training and adaptive techniques.
OTHER	stretching exercise	Techniques involving passive or active stretching of muscles to enhance flexibility, reduce spasticity, and prevent contractures.
OTHER	rTMS	Non-invasive brain stimulation method using magnetic pulses to modulate cortical excitability and promote neural plasticity.
DEVICE	bimanual therapy	A training approach that involves simultaneous use of both hands to enhance coordination and functional hand movements through guided exercises, including device-assisted and robot-assisted therapy

Timeline

• Start date: 2025-07-15
• Primary completion: 2027-07-31
• Completion: 2027-07-31
• First posted: 2025-07-08
• Last updated: 2025-07-08

Locations

1 site across 1 country: Taiwan