NCT07054073

HCMR Re-Imaging Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 314 (estimated)
• Sponsor: Christopher Kramer · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims to learn what might predict heart problems (like sudden death from a fast heart rhythm or heart failure) in people with a genetic condition called hypertrophic cardiomyopathy (HCM). HCM causes the heart muscle to become thick, which can make the heart stiff and harder to work properly. It can also affect the heart's electrical system. This study is looking to enroll patients that were previously part of a research project called "HCMR - Novel Predictors of Outcome in Hypertrophic Cardiomyopathy." The results of that study are still being reviewed, but they might show that people who had a substance called Gadolinium (MRI contrast or dye) collected in their heart muscle may have a higher risk for heart problems, including sudden cardiac death. This is called "late gadolinium enhancement" (LGE). This study is aiming to do follow-up imaging on those patients to better understand how LGE affects people with HCM.

Conditions

• Hypertrophic Cardiomyopathy (HCM)

Interventions

Type	Name	Description
OTHER	None - observational study	None - observational study

Timeline

• Start date: 2026-03-30
• Primary completion: 2027-03-01
• Completion: 2027-07-01
• First posted: 2025-07-08
• Last updated: 2026-03-18

Locations

8 sites across 2 countries: United States, United Kingdom