NCT07052890

Curcumin, Vitamin D and Green Tea in IBS-D

Role of a Food Supplement Containing Curcumin, Green Tea and Vitamin D on Symptom Control in Diarrhoea Predominant Irritable Bowel Syndrome (IBS-D)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Dr Anthony Hobson · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Irritable Bowel Syndrome (IBS) is a highly prevalent condition of the gastrointestinal tract that has significant impact on sufferer's quality of life. The diarrhoea variant (IBS-D) makes up around one third of all IBS sufferers. There is currently a lack of both effective pharmacological and non-pharmacological treatments for IBS-D. Three food supplements: Green tea, vitamin D and curcumin have all been shown to demonstrate benefit in either reducing symptoms in IBS or diarrhoea as individual ingredients, but have never been tested in combination to assess their effectiveness in IBS. This research study aims to examine the effectiveness of green tea, vitamin D and curcumin in combination compared to a placebo capsule in individual suffering from IBS-D. The study will aim to enroll 78 participants with IBS-D and utilise a placebo-controlled double blind design. The study will consist of a 2 week screening period, a 4 week randomised treatment period (50% participants to receive placebo, 50% to receive active treatment), followed by a 4 week open label treatment period (all participants to receive the active study product).

Conditions

• Irritable Bowel Syndrome (IBS)
• Irritable Bowel Syndrome With Diarrhea (IBS-D)

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Curcumin, vitamin d and green tea extract	A combination of the following ingrediants per 4 capsules: CurcuWin® 1000mg - of which 200mg Curcuminoids Green Tea Extract 400mg - (0.1-0.5% caffeine) Vitamin D₃ 50 µg 2000IU
DIETARY_SUPPLEMENT	Placebo Capsule(s)	Placebo - identical capsules containing inert color matched power

Timeline

• Start date: 2024-09-19
• Primary completion: 2025-12-08
• Completion: 2026-01-30
• First posted: 2025-07-08
• Last updated: 2026-03-11

Locations

3 sites across 1 country: United Kingdom