Trials / Recruiting
RecruitingNCT07050381
The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM
Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.
Conditions
- Arteriovenous Malformation of Central Nervous System
- Aneurysm, Ruptured
- Aneurysmatic Subarachnoid Haemorrhage
- Aneurysm Cerebral
Timeline
- Start date
- 2025-06-13
- Primary completion
- 2025-08-31
- Completion
- 2026-12-31
- First posted
- 2025-07-03
- Last updated
- 2025-07-03
Locations
2 sites across 1 country: China
Source: ClinicalTrials.gov record NCT07050381. Inclusion in this directory is not an endorsement.