NCT07049107

Pharmacokinetics Impact of HRS-8427 on Bupropion and Midazolam in Healthy Subjects

A Study on the Pharmacokinetic Effects of HRS-8427 Injection on Bupropion and Midazolam in Healthy Subjects

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Jiangsu HengRui Medicine Co., Ltd. · Industry
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study is a single-center, open-label, sequential drug interaction study The primary objectives are: To evaluate the pharmacokinetic effects of HRS-8427 injection on the liver drug enzymes CYP2B6 substrate bupropion and CYP3A4 substrate midazolam in healthy subjects.

Conditions

• Health Volunteer

Interventions

Type	Name	Description
DRUG	HRS-8427	HRS-8427

Timeline

• Start date: 2025-06-23
• Primary completion: 2025-07-21
• Completion: 2025-07-21
• First posted: 2025-07-03
• Last updated: 2026-03-16

Locations

1 site across 1 country: China