NCT07045727

Prehabilitation With Aerobic and Resistance Exercise for Improving Physical Fitness and Quality of Life Outcomes in Older Patients Undergoing CAR-T Therapy for Relapsed or Refractory Multiple Myeloma

Prehabilitation in Patients With Multiple Myeloma Receiving CAR-T Therapy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial evaluates whether prehabilitation with aerobic and resistance exercise improves physical fitness and quality of life outcomes in older patients planning to undergo chimeric antigen receptor (CAR)-T therapy for multiple myeloma that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory). CAR-T therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. Large numbers of the CAR-T cells are grown in the laboratory and given to the patient by infusion for treatment of certain cancers. While CAR-T therapy is commonly used to treat multiple myeloma, it can result in toxicities that lead to hospitalization, nerve and muscle impairment, and decreased physical function. Prehabilitation programs use targeted interventions to improve functional status prior to medical or surgical treatments. In this study, patients participate in personalized aerobic and resistance prehabilitation activities in the weeks leading up to their CAR-T infusion. This program may improve physical fitness and quality of life, both prior to and after CAR-T infusion, in older patients with relapsed or refractory multiple myeloma.

Conditions

• Recurrent Multiple Myeloma
• Refractory Multiple Myeloma

Interventions

Type	Name	Description
PROCEDURE	Accelerometry	Ancillary studies
OTHER	Aerobic Exercise	Participate in aerobic training program
PROCEDURE	Biospecimen Collection	Undergo collection of blood and urine samples
OTHER	Electronic Health Record Review	Ancillary studies
OTHER	Exercise Counseling	Receive health coaching check-in calls
OTHER	Internet-Based Intervention	Use Connected mHealth app
OTHER	Interview	Ancillary studies
OTHER	Physical Performance Testing	Ancillary studies
OTHER	Resistance Training	Participate in resistance training program
OTHER	Survey Administration	Ancillary studies
PROCEDURE	Tailored Intervention	Receive personalized exercise plan

Timeline

• Start date: 2025-08-18
• Primary completion: 2026-09-15
• Completion: 2026-09-15
• First posted: 2025-07-01
• Last updated: 2026-03-30

Locations

1 site across 1 country: United States