NCT07044934

Uric Acid and Menopausal Age in Acute Kidney Injury

Impact of Preoperative Uric Acid on Postoperative Acute Kidney Injury in Female Patients Undergoing Non-cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 127,052 (actual)
• Sponsor: Asan Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: —

Summary

Preoperative serum uric acid significantly impacted acute kidney injury in female patients undergoing non-cardiac surgery, with differential effects observed before and after menopause.

Detailed description

Preoperative serum uric acid has been increasingly recognized as a potential biomarker associated with acute kidney injury in various clinical settings. However, the sex-specific and hormonal influences on this association remain unclear, particularly in the context of non-cardiac surgery. Female patients, who experience significant physiological changes across the menopausal transition, may exhibit different renal susceptibilities to elevated serum uric acid levels. In this retrospective cohort study, the investigators aimed to evaluate the association between preoperative serum uric acid levels and postoperative acute kidney injury in female patients undergoing non-cardiac surgery, with a particular focus on menopausal status. Women were stratified into premenopausal and postmenopausal groups based on age and clinical criteria. The investigators hypothesized that the threshold and pattern of serum uric acid-associated acute kidney injury risk may differ between these two populations due to differences in hormonal status and baseline renal reserve.

Conditions

• Uric Acid

Interventions

Type	Name	Description
OTHER	No Intervention: Observational Cohort	This observational cohort includes female patients undergoing non-cardiac surgery. No intervention was administered as part of the study protocol. Preoperative serum uric acid levels were measured, and patients were followed for the development of postoperative acute kidney injury. Data were analyzed retrospectively to assess the association between uric acid levels and acute kidney injury, with subgroup analyses based on menopausal status (premenopausal vs. postmenopausal women).

Timeline

• Start date: 2024-07-30
• Primary completion: 2024-12-20
• Completion: 2025-02-20
• First posted: 2025-07-01
• Last updated: 2025-07-02

Locations

1 site across 1 country: South Korea