NCT07044089

Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery

Comparison of Individualized PEEP Application Versus Fixed PEEP Application for Lung-Protective Ventilation in Patients Undergoing On-Pump Coronary Artery Bypass Grafting Surgery

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 86 (estimated)
• Sponsor: Kocaeli University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery. Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.

Detailed description

The primary goal of the researchers: To compare the effects of fixed PEEP versus driving pressure guided individualized PEEP in lung protective mechanical ventilation during on-pump open heart surgery effect of PaO2/ FiO2 ratio end of surgery. The secondary goals of the researchers: To compare intraoperative hemodynamics, lung compliance and airway pressures, extubation time and respiratory complications \[development of atelectasis, need for noninvasive mechanical ventilation (high-flow nasal cannula or CPAP application), need for re-intubation\], length of stay in the ICU and discharge times.

Conditions

• Peep Titration in Lung Protective Ventilation

Timeline

• Start date: 2025-07-23
• Primary completion: 2027-03-01
• Completion: 2027-09-01
• First posted: 2025-06-29
• Last updated: 2025-08-08

Locations

1 site across 1 country: Turkey (Türkiye)