NCT07043712

Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants

Human Pulse Consumption, the Microbiome, and Meal Satiety

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (estimated)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: 20 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to investigate the effects of pulse consumption versus no pulse consumption on the gut microbiome, meal satiety, and short-chain fatty acid metabolomics.

Detailed description

1. Investigate the acute and chronic effects of pulse consumption on the microbiome and plasma SCFA metabolomics in overweight subjects fed a high pulse (n=22) diet versus a no pulse containing diet (n=22). 2. Furthermore, we will quantitate the rate of production of plasma SCFA, markers of satiety (PYY, GLP-1 and ghrelin), blood lipids, and carbohydrate (CHO) metabolism (glucose levels and oxidation) during a standardized meal to determine the effects of consuming pulses on appetite and satiety after acute and chronic dietary consumption. 3. We will conduct subjective appetite assessments to investigate appetite control over the short- and long-term.

Conditions

• Microbial Colonization
• Metabolic Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	High pulse consumption	Subjects are provided a high pulse diet for 4 weeks.collection, and anthropometrics measured.

Timeline

• Start date: 2023-02-01
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-06-29
• Last updated: 2026-01-15

Locations

1 site across 1 country: United States