NCT07043595

H-Reflex Suppression by Bone Myoregulation Reflex During Mechanical Loading in Standing Humans

Neuronal Mechanisms Underlying H-Reflex Suppression During Mechanical Loading: The Role of Bone Myoregulation Reflex in Standing Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Other Government
• Sex: All
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate how standing posture and mechanical loading affect reflex responses in the lower limb. Specifically, it focuses on the H-reflex-a type of spinal cord reflex-and how it changes during quiet standing and whole-body vibration. Ten healthy adult volunteers will participate. Researchers will record electrical responses from the calf muscle (soleus) while participants stand still or are exposed to gentle vibration. The goal is to better understand how the nervous system and skeletal system interact in regulating balance and movement.

Detailed description

This study investigates the neural mechanisms responsible for suppression of the H-reflex-a spinal monosynaptic reflex-during mechanical loading in the standing position. Previous research has shown that H-reflex amplitude decreases with increasing postural demand, such as during walking or standing compared to lying down. One hypothesis suggests that this suppression may be mediated not only by vestibular and cutaneous afferents, but also by a bone-derived reflex mechanism called the Bone Myoregulation Reflex (BMR). In this study, 10 healthy adult volunteers will undergo H-reflex measurements while standing in various loading conditions, including quiet standing and during whole-body vibration (WBV). Participants will stand with one foot isolated from vibration while the other foot is on a vibrating platform. H-reflexes will be recorded from the soleus muscle using standard surface electromyography. The primary aim is to determine whether BMR contributes to H-reflex suppression during loading. The findings may provide insight into the interaction between skeletal loading and spinal reflex modulation, with potential relevance to balance, gait, and rehabilitation science.

Conditions

• H-reflex
• Spinal Reflexes
• Posture
• Weight-Bearing
• Neuromuscular Physiology

Interventions

Type	Name	Description
PROCEDURE	Whole-Body Vibration (WBV)	Participants will stand quietly in an upright position while whole-body vibration (WBV) is applied through a vibration platform. The vibration stimulus is delivered while the participant's left foot remains on the vibration surface and the right foot is elevated or isolated. H-reflex recordings are taken from the soleus muscle during the procedure to assess spinal reflex modulation due to mechanical loading.

Timeline

• Start date: 2025-06-24
• Primary completion: 2025-07-07
• Completion: 2025-07-10
• First posted: 2025-06-29
• Last updated: 2025-09-04

Locations

1 site across 1 country: Turkey (Türkiye)