NCT07043049

Comparison of Prophylactic Use of Tramadol Versus Ketamine for Prevention of Post Spinal Anesthesia Shivering

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 92 (actual)
• Sponsor: Syed Muhammad Abbas · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to compare the effectiveness of tramadol versus ketamine in preventing shivering after spinal anesthesia in adult patients (ages 20-65) undergoing elective lower abdominal or inguinoscrotal surgeries. The main questions it aims to answer are: * Does prophylactic intravenous tramadol reduce the incidence and severity of shivering more effectively than ketamine after spinal anesthesia? * Are there differences in side effects, such as sedation or nausea, between tramadol and ketamine? Researchers will compare the tramadol group to the ketamine group to see which drug is more effective and safer for shivering prevention. Participants will: * Be randomly assigned to receive either tramadol (1 mg/kg) or ketamine (0.5 mg/kg) five minutes after spinal anesthesia. * Have their shivering severity assessed at 15, 30, 45, and 60 minutes using a standardized scale. * Be monitored for sedation, nausea, and other possible side effects.

Conditions

• Shivering

Interventions

Type	Name	Description
DRUG	Tramadol	Tramadol 1 mg/kg IV given 5 minutes after spinal anesthesia for prevention of post-anesthesia shivering
DRUG	Ketamine	Ketamine 0.5 mg/kg IV administered 5 minutes after spinal anesthesia for prevention of post-anesthesia shivering.

Timeline

• Start date: 2022-06-29
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2025-06-29
• Last updated: 2025-06-29

Locations

2 sites across 1 country: Pakistan