NCT07040241

Confocal Laser Endomicroscopy Assisted Ultrasound Guided Pleural Biopsy

Diagnostic Yield and Safety of Probe-based COnfocaL LAser Endomicroscopy and Ultrasound-guided Pleural BiOpsy in Diagnosing Patients With Unknown pleuRAl Effusion: a Protocol of a Multicenter, Randomized cONtrolled Trial (COLLABORATION-Ⅱ）

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 260 (estimated)
• Sponsor: China-Japan Friendship Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to evaluate the diagnostic yield and safety of confocal laser endomicroscopy and ultrasound-guided pleural biopsy in diagnosing patients with unknown pleural effusion.

Conditions

• Pleural Effusion Disorder

Interventions

Type	Name	Description
PROCEDURE	Confocoal laser endomicroscopy-assisted ultrasound-guided pleural biopsy	Using the probe-based confocal laser endomicroscopy to detect the pleural, and ensure the biopsy location. Then, use the pleural biopsy tool to complete the pleural biopsy. The whole procession will under the ultrasound guidance.
PROCEDURE	Ultrasound-guided pleural biopsy	Using ultrasound to detect the biopsy site and perform pleural biopsy.

Timeline

• Start date: 2025-07-01
• Primary completion: 2027-07-01
• Completion: 2027-07-01
• First posted: 2025-06-27
• Last updated: 2025-06-27