NCT07039513

EVOLUTION OF D-DIMER AS A MARKER OF BLEEDING RISK ON ECMO

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

ECMO (extracorporeal membrane oxygenation) is a life-saving device, used in intensive care to treat severe respiratory or cardiac failure. However, it carries a high risk of serious life-threatening bleeding. Bleeding complications have been attributed to coagulopathy triggered either by the underlying pathology or by the extracorporeal circuit itself, as well as excessive or inappropriate anticoagulation initiated to prevent thrombotic complications. The objective of this cohort is to confirm the interest of the evolution of D-dimers as a prognostic marker of serious bleeding events in patients on veno-venous (VV) or veno-arterial (VA) ECMO, and to determine the threshold.

Conditions

• ECMO
• Mplementation of a Veno-venous VV or Veno-arterial VA
• INTENSIVE CARE

Interventions

Type	Name	Description
OTHER	Blood sampling collection	Collection of an additional of 2.7mL citrate tube of blood for a D-dimer dosage.

Timeline

• Start date: 2025-11-27
• Primary completion: 2027-05-01
• Completion: 2027-06-01
• First posted: 2025-06-26
• Last updated: 2025-12-01

Locations

1 site across 1 country: France