NCT07035938

T-cell Developmental Status in Patients With Malignant Hematological Tumors

An Observational, Bidirectional Cohort Study to Evaluate T-cell Developmental Status in Patients With Malignant Hematological Tumors

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 75 (estimated)
• Sponsor: The First Affiliated Hospital of Xiamen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

To evaluate the immune status and prognosis of patients with malignant hematological tumors, thereby guiding clinical therapeutic strategies.

Detailed description

Primary Objective: To evaluate the immune status and prognosis of patients with newly diagnosed or relapsed B-cell lymphoma and multiple myeloma by dynamically monitoring peripheral blood thymus seeding progenitors (TSP), recent thymic emigrants (RTE), T-cell receptor rearrangement excision circles (TREC), naive T-cells, and developmental/functional T-cell subsets before and after treatment, thereby guiding clinical therapeutic strategies. Secondary Objective: To monitor remission rates, survival outcomes, and infection rates in patients with hematological malignancies, and to explore their association with dynamic changes in developmental/functional T-cell subsets.

Conditions

• Hematologic Malignancy

Interventions

Type	Name	Description
OTHER	observational study	observational study

Timeline

• Start date: 2025-06-22
• Primary completion: 2028-06-30
• Completion: 2028-06-30
• First posted: 2025-06-25
• Last updated: 2025-07-23

Locations

1 site across 1 country: China