NCT07035743

Bronchial Response to Exercise After Double Lung Transplantation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the airway response to exercise and its association with breathlessness in double lung transplant recipients by comparing responses during 5-minute and 15-minute exercise durations.

Detailed description

Participants will undergo a constant workload challenge set at 60% of their peak oxygen uptake in 2 separate sessions: a 5-minute and a 15-minute exercise session, conducted in a random order. Ratings of perceived exertion will be measured every 5 minutes during exercise. Forced expiratory volume in 1 second will be performed before exercise, immediately post-exercise, and at 5, 10, 15, 20, and 30 minutes post-exercise in order to assess the airway response.

Conditions

• Airway Response
• Lung Transplant Recipients
• Lung Transplant
• Challenge Test

Interventions

Type	Name	Description
OTHER	Exercise	5 minutes of constant workload exercise at 60% of peak oxygen uptake from cardiopulmonary exercise testing
OTHER	Exercise	15 minutes of constant workload exercise at 60% of peak oxygen uptake from cardiopulmonary exercise testing

Timeline

• Start date: 2025-06-05
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2025-06-25
• Last updated: 2025-06-25

Locations

1 site across 1 country: Taiwan