NCT07034911

Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery

Impact of Sub-anaesthetic Dose of Ketamine Versus Ephedrine on Post Spinal Hypotension in Caesarean Delivery

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Comparing ketamine and ephedrine to decrease the incidence of post spinal hypotension after caesarean section delivery.

Detailed description

To compare the effect of ketamine versus ephedrine in decreasing the incidence of hypotension in caesarean section delivery a study group including 50 participants will receive ketamine and 50 group will receive ephedrine after the consent and detailed history the two groups will receive preload of 500ml enter acetate then dormicum for sedation then spinal anesthesia will be performed initial blood pressure and heart rate will be measured then every five minutes

Conditions

• Post Spinal Hypotension

Interventions

Type	Name	Description
DRUG	Ketalar	women receiving sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml of normal saline.
DRUG	Ephedrine	women receiving bolus of 15mg of ephedrine

Timeline

• Start date: 2024-04-01
• Primary completion: 2024-09-01
• Completion: 2024-09-15
• First posted: 2025-06-24
• Last updated: 2025-06-24

Locations

1 site across 1 country: Egypt