Trials / Active Not Recruiting
Active Not RecruitingNCT07034586
Prospective Evaluation of Adventitial Histopathology in Borderline Ascending Aortic Dilatatio
A Prospective Analysis of Adventitial Pathology in Patients Undergoing Coronary Bypass With Borderline Ascending Aortic Dilatation
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 102 (actual)
- Sponsor
- Samsun University · Academic / Other
- Sex
- All
- Age
- 20 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
This prospective study investigates microscopic changes in the outer layer (adventitia) of the ascending aorta in patients undergoing coronary artery bypass grafting (CABG) surgery. The study includes two groups of patients: (1) those with borderline ascending aortic dilatation (4.0-5.0 cm), and (2) a control group with normal aortic diameter (\<4.0 cm), all undergoing the same surgical procedure. During CABG, a small circular punch is routinely made in the ascending aorta for the proximal saphenous vein graft anastomosis. The tissue removed from this punch site is collected and used for histopathological and immunohistochemical analysis. The study aims to determine whether adventitial changes correlate with aortic size and whether these changes can help identify patients at risk for future aortic dissection or rupture. The findings may guide surgical decision-making in patients with borderline aortic enlargement.
Conditions
- Ascending Aortic Aneurysm
- Aortic Adventitial Pathology
- Coronary Artery Bypass Grafting (CABG)
- Borderline Aortic Dilatation
Timeline
- Start date
- 2023-08-01
- Primary completion
- 2025-08-01
- Completion
- 2025-09-01
- First posted
- 2025-06-24
- Last updated
- 2025-06-24
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT07034586. Inclusion in this directory is not an endorsement.