NCT07033988

Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia

Insights Into Cerebral Clot Biomarkers and Inflammatory Pathways

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 380 (estimated)
• Sponsor: IRCCS San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an observational, prospective and retrospective, single-center study of thrombotic material and blood samples obtained from patients undergoing mechanical endovascular thrombectomy for ischemic stroke caused by large vessel occlusion or stenosis. The overarching aim of this study is to advance the understanding of the pathogenesis of cerebral ischemia and to support the development of novel therapeutic strategies for cerebrovascular disease. Specifically, the research seeks to elucidate the pathophysiological mechanisms involved in thrombus formation and stabilization that lead to ischemic events, identify thrombus compositions associated with distinct stroke etiologies, and determine features predictive of resistance to current intravenous thrombolytic therapies. In addition, the study aims to discover novel therapeutic targets and to identify circulating blood biomarkers indicative of an elevated risk of thrombosis.

Conditions

• Stroke Acute

Timeline

• Start date: 2025-06-01
• Primary completion: 2030-05-01
• Completion: 2030-05-01
• First posted: 2025-06-24
• Last updated: 2025-06-24

Locations

1 site across 1 country: Italy