NCT07032571

Reset: Enhancing Weight Loss in a Digital Intervention

Enhancing Weight Loss in a Digital Intervention Among Adults With Overweight or Obesity

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 208 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity. The investigators will examine the impact on weight loss of four dietary strategies: 1) limiting Red Zone Foods (i.e., foods that are high in calories and low in nutrition), 2) limiting eating windows, 3) increasing protein intake, and 4) increasing fiber intake. Each of these strategies will include goal setting, daily self-monitoring, and tailored feedback. The investigators will recruit 208 participants. Broadly, adults with overweight or obesity who live in the U.S. will be eligible. The weight loss intervention will last 12 weeks. All participants will be asked to track their body weight daily and complete weekly behavioral lessons and action plans to promote healthy eating and physical activity. All study tasks will occur remotely. Assessment of body weight and survey measures will occur at the beginning of the trial ("baseline"), and at 1 month and 3 months. The Multiphase Optimization Strategy (MOST) framework will be used to identify which combination of the dietary behavior strategies results in the greatest weight loss. In total, there will be 16 treatment conditions.

Conditions

• Obesity
• Overweight
• Weight Loss
• Health Behavior
• Lifestyle Intervention

Interventions

Type	Name	Description
BEHAVIORAL	Core Behavioral Weight Loss Intervention	All participants receive a 12-week core behavioral weight loss intervention consisting of the following: daily self-monitoring of weight; weekly behavioral lessons and action plans to promote healthy eating and physical activity; and tailored feedback. The intervention will be delivered remotely via email and/or text message.
BEHAVIORAL	Limit Red Zone Foods	Participants randomized to receive this component are given a goal to limit their Red Zone Foods (i.e., foods high in calories and low in nutrition) and are instructed to self-monitor them daily.
BEHAVIORAL	Limit Eating Window	Participants randomized to receive this component are given a goal to limit their eating windows (i.e., follow time-restricted eating) and are instructed to self-monitor them daily.
BEHAVIORAL	Increase Protein	Participants randomized to receive this component are given a goal to increase their protein intake and are instructed to self-monitor it daily.
BEHAVIORAL	Increase Fiber Intake	Participants randomized to receive this component are given a goal to increase their fiber intake and are instructed to self-monitor it daily.

Timeline

• Start date: 2026-04-01
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2025-06-24
• Last updated: 2026-03-03

Locations

1 site across 1 country: United States