NCT07030153

Association of Genetic Variants With Myopia

Genetic Variants and Their Association With Myopia Risk, Progression, and Optimal Interventions in Children

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Beijing Visionly Plus Eye Hospital · Academic / Other
• Sex: All
• Age: 6 Years – 18 Years
• Healthy volunteers: Accepted

Summary

This study aims to identify genetic factors linked to myopia, including those that influence a person's risk of developing it and how quickly it progresses (like changes in eye length). It will also examine how different treatments-such as low-dose atropine drops, orthokeratology lenses, specialized glasses, and increased outdoor time-interact with these genes. Finally, the research will develop a genetic risk score to help tailor personalized myopia prevention and treatment plans.

Conditions

• Myopia

Interventions

Type	Name	Description
GENETIC	Oral swab DNA analyzed for myopia-related gene variants	Beyond detecting links between gene variants and myopia development, the testing analyzes how these variants influence treatment effectiveness. The aim is to enable early risk prediction and personalized treatment guidance for children through oral DNA testing.

Timeline

• Start date: 2025-07-01
• Primary completion: 2028-08-31
• Completion: 2028-12-31
• First posted: 2025-06-22
• Last updated: 2025-06-22

Locations

2 sites across 1 country: China