NCT07030010

Effect of a Liquid Tonic Drink on Post-meal Glucose and Insulin Responses

Examining the Efficacy of a Commercially Available Multi-ingredient Liquid Tonic Drink on Postprandial Glycemia in Men and Women With Overweight and/or Obesity.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Australian Catholic University · Academic / Other
• Sex: All
• Age: 30 Years – 64 Years
• Healthy volunteers: Not accepted

Summary

A randomised, double blinded, placebo-controlled crossover design clinical trial conducted at the Mary MacKillop Institute for Health Research (MMIHR, Australian Catholic University) for individuals with overweight/ obesity. This study will measure the postprandial glucose and hormone responses to a high-carbohydrate meal with/ without a liquid tonic drink.

Detailed description

Twenty individuals living with overweight/ obesity will be invited to attend the university laboratories on 2 separate occasions to participate in a postprandial (meal) challenge. Participants will consume the same high-carbohydrate meal on each visit, with or without a liquid tonic drink. This will be a cross-over design study, where participants will consume a placebo drink on the alternate visit. Participants will remain in the laboratory for 3-hours following the meal with a venous cannula in place, and have blood samples taken at regular timepoints. Blood samples will be analysed for glucose and appetite hormones. Participants will also wear a continuous glucose monitor throughout the period which encapsulates both study trials.

Conditions

• Overweight or Obese Adults

Interventions

Type	Name	Description
OTHER	Breakfast meal challenge with tonic drink	High-carbohydrate containing breakfast meal with the addition of the tonic drink
OTHER	Breakfast meal challenge with placebo drink	High-carbohydrate containing breakfast meal with the addition of the placebo drink

Timeline

• Start date: 2025-07-08
• Primary completion: 2025-12-19
• Completion: 2025-12-19
• First posted: 2025-06-19
• Last updated: 2025-07-23

Locations

1 site across 1 country: Australia